![]() ![]() Ventilation at D0 with P20 increased IC and compliance when applied to saline-treated but not endotoxin-exposed pups. High-pressure ventilation (P20 and P24) tended to increase IC and compliance in all saline-treated groups. At D7, endotoxin was associated with reduced compliance. Prior to prolonged ventilation at D0, endotoxin-exposed rats had decreased compliance and inspiratory capacity (IC) compared to controls. At birth (D0) or 7 days (D7), rats received 90 min of lung protective ventilation P20 ventilation or P24 ventilation (Pplat = 24 cmH 2O, PEEP = 0, only applied to D7). Fetal rats were exposed to 10 μg endotoxin or saline via intra-amniotic injection. We have previously shown that antenatal endotoxin (ETX) causes abnormal lung structure and function in 2-week-old rats, but whether ETX impairs lung mechanics at birth and increases risk for VILI is unknown. Perinatal inflammation due to chorioamnionitis and ventilator-induced lung injury (VILI) at birth is independent risk factors for the development of bronchopulmonary dysplasia (BPD). 4Division of Pediatric Pulmonary and Sleep Medicine, Department of Pediatrics, School of Medicine, University of Colorado, Aurora, CO, United States.3Department of Bioengineering, College of Engineering, Design, and Computing, University of Colorado Denver | Anschutz Medical Campus, Aurora, CO, United States.2Division of Neonatology, Department of Pediatrics, School of Medicine, University of Colorado, Aurora, CO, United States.1Department of Pediatrics, Pediatric Heart Lung Center, School of Medicine, University of Colorado, Aurora, CO, United States.Mandell 1,2 *, Courtney Mattson 3, Gregory Seedorf 1,4, Sharon Ryan 1,2, Tania Gonzalez 1,2, Alison Wallbank 3, Elisa M. ![]()
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